Here we discuss the hypothesis that the RNA components of the Ro ribonucleoproteins (RNPs), the Y RNAs, can be processed into microRNAs (miRNAs). Although Ro RNPs, whose main protein components Ro60 and La are targeted by the immune system in several autoimmune diseases, were discovered many years ago, their function is still poorly understood. Indeed, recent data show that miRNA-sized small RNAs can be generated from Y RNAs. This hypothesis leads also to a model in which Ro60 acts as a (...) modulator in the Y RNA-derived miRNA biogenesis pathway. The implications of these Y RNA-derived miRNAs, which may be specifically produced under pathological circumstances such as in autoimmunity or during viral infections, for the enigmatic function of Ro RNPs are discussed. (shrink)

This volume honours the life and work of Solomon Feferman, one of the most prominent mathematical logicians of the latter half of the 20th century. In the collection of essays presented here, researchers examine Feferman’s work on mathematical as well as specific methodological and philosophical issues that tie into mathematics. Feferman’s work was largely based in mathematical logic, but also branched out into methodological and philosophical issues, making it well known beyond the borders of the mathematics community. With regard to (...) methodological issues, Feferman supported concrete projects. On the one hand, these projects calibrate the proof theoretic strength of subsystems of analysis and set theory and provide ways of overcoming the limitations imposed by Gödel’s incompleteness theorems through appropriate conceptual expansions. On the other, they seek to identify novel axiomatic foundations for mathematical practice, truth theories, and category theory. In his philosophical research, Feferman explored questions such as “What is logic?” and proposed particular positions regarding the foundations of mathematics including, for example, his “conceptual structuralism.” The contributing authors of the volume examine all of the above issues. Their papers are accompanied by an autobiography presented by Feferman that reflects on the evolution and intellectual contexts of his work. The contributing authors critically examine Feferman’s work and, in part, actively expand on his concrete mathematical projects. The volume illuminates Feferman’s distinctive work and, in the process, provides an enlightening perspective on the foundations of mathematics and logic. (shrink)

Die Buchreihe "Philosopische Anthropologie" wird mit einem Band eröffnet, der die Philosophische Anthropologie im Streit vorstellt. Geführt wird dieser Streit um das Paradigma der Philosophischen Anthropologie und um ihre Methoden im Unterschied sowohl zu anderen Philosophien als auch zu den verschiedenen Erfahrungswissenschaften. Ihre Grenzbestimmungen und Grenzübergänge finden schließlich anhand ausgewählter Themen eine exemplarische Erprobung.

Atheïstisch-filosofische poging tot begrip van de relevantie en continuering van christelijke religiositeit in een moderne en seculiere Europese cultuur.